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author:"Sekne Z"

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Current Database

  • EMDB [14]

Current status

  • REL [14]

Sample type

  • Complex [14]
  • Protein [14]
  • RNA [14]
  • DNA [10]

Organism

  • Homo sapiens [14]

EM Method

  • Single-particle [14]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [11]
  • ≥ 4Å and < 5Å [1]
  • ≥ 6Å and < 8Å [1]

Model molecular weight

  • 250-500 kDa [7]
  • 500-1000 kDa [2]

Release Date

  • 2025 [8]
  • 2024 [2]
  • 2022 [4]

Author by name

  • Ghanim GE [14]
  • Nguyen THD [14]
  • Sekne Z [14]
  • Balch S [10]
  • Das R [8]
  • Ding Y [8]
  • Franco-echevarria E [8]
  • Kretsch RC [8]
  • Ludzia P [8]
  • Sun W [8]
  • Thorkelsson S [8]
  • Yu H [8]
  • Sigurdur TR [6]
  • Van Roon Am [6]
  • Van Roon Amm [4]
  • Thorkelsson SR [2]

Author by ORCID

  • Nguyen THD [14]
  • Ghanim GE [14]
  • Sekne Z [12]
  • Franco-echevarria E [8]
  • Das R [8]
  • Ludzia P [8]
  • Yu H [8]
  • Kretsch RC [8]
  • Thorkelsson S [8]
  • Ding Y [8]
  • Sun W [8]
  • Balch S [8]
  • Van Roon Am [4]

Journal

  • SCIENCE [12]
  • NAT COMMUN [2]

Software

  • RELION [14]
  • CTFFIND [8]
  • CRYOSPARC [1]

Microscope

  • FEI TITAN KRIOS [13]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [14]

Film or detector model

  • GATAN K3 6K X 4K [14]

External links

  • AlphaFold DB [14]
  • PDBe-Kb [14]
  • UniProt [14]
  • PDB [9]
  • Pfam [9]
  • Complex Portal [7]
  • Gene Ontology [4]
  • InterPro [4]
  • SCOP2 [1]
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Showing 1 - 10 of 14. Page 1 of 2
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EMD-52976
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3D View
Consensus dimer structure of human telomerase
Release date: July 16, 2025
Resolution: 6.2 Å
EM Method: Single-particle

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52978
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The catalytic core with C2 symmetry of human telomerase dimer
Release date: July 16, 2025
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9qax
Q-score: 0.259

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52979
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Catalytic core 1 of dimeric human telomerase
Release date: July 16, 2025
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9qay
Q-score: 0.226

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52980
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3D View
Catalytic core 2 of dimeric human telomerase
Release date: July 16, 2025
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9qaz
Q-score: 0.233

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52981
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3D View
Catalytic core 1 of human telomerase dimer from particles common to both catalytic cores of the dimer
Release date: July 16, 2025
Resolution: 4.1 Å
EM Method: Single-particle

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52982
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3D View
Catalytic core 2 of the telomerase dimer with common particles to both catalytic cores of the dimer
Release date: July 16, 2025
Resolution: 3.9 Å
EM Method: Single-particle

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52983
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H/ACA RNP protomer of human telomerase dimer
Release date: July 16, 2025
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9qb2
Q-score: 0.448

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52984
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3D View
Dimer structure of H/ACA RNP lobe of human telomerase
Release date: July 16, 2025
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9qb3
Q-score: 0.261

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-17190
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The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation
Release date: Jan. 31, 2024
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8oue
Q-score: 0.574

Ghanim GE, Sekne Z, Balch S, van Roon AM, Nguyen THD

Nat Commun (2024) 15 pp. 746-746 [ DOI: doi:10.1038/s41467-024-45002-x Pubmed: 38272871 ]

EMD-17191
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The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in an open conformation
Release date: Jan. 31, 2024
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ouf
Q-score: 0.543

Ghanim GE, Sekne Z, Balch S, van Roon AM, Nguyen THD

Nat Commun (2024) 15 pp. 746-746 [ DOI: doi:10.1038/s41467-024-45002-x Pubmed: 38272871 ]

Sort by: Download
Showing 1 - 10 of 14. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [14]

Current status

  • REL [14]

Sample type

  • Complex [14]
  • Protein [14]
  • RNA [14]
  • DNA [10]

Organism

  • Homo sapiens [14]

EM Method

  • Single-particle [14]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [11]
  • ≥ 4Å and < 5Å [1]
  • ≥ 6Å and < 8Å [1]

Model molecular weight

  • 250-500 kDa [7]
  • 500-1000 kDa [2]

Release Date

  • 2025 [8]
  • 2024 [2]
  • 2022 [4]

Author by name

  • Ghanim GE [14]
  • Nguyen THD [14]
  • Sekne Z [14]
  • Balch S [10]
  • Das R [8]
  • Ding Y [8]
  • Franco-echevarria E [8]
  • Kretsch RC [8]
  • Ludzia P [8]
  • Sun W [8]
  • Thorkelsson S [8]
  • Yu H [8]
  • Sigurdur TR [6]
  • Van Roon Am [6]
  • Van Roon Amm [4]
  • Thorkelsson SR [2]

Author by ORCID

  • Nguyen THD [14]
  • Ghanim GE [14]
  • Sekne Z [12]
  • Franco-echevarria E [8]
  • Das R [8]
  • Ludzia P [8]
  • Yu H [8]
  • Kretsch RC [8]
  • Thorkelsson S [8]
  • Ding Y [8]
  • Sun W [8]
  • Balch S [8]
  • Van Roon Am [4]

Journal

  • SCIENCE [12]
  • NAT COMMUN [2]

Software

  • RELION [14]
  • CTFFIND [8]
  • CRYOSPARC [1]

Microscope

  • FEI TITAN KRIOS [13]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [14]

Film or detector model

  • GATAN K3 6K X 4K [14]

External links

  • AlphaFold DB [14]
  • PDBe-Kb [14]
  • UniProt [14]
  • PDB [9]
  • Pfam [9]
  • Complex Portal [7]
  • Gene Ontology [4]
  • InterPro [4]
  • SCOP2 [1]