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› 9qay

Electron Microscopy
3.8Å resolution

Catalytic core 1 of dimeric human telomerase

Released:
DOI: 10.2210/pdb9qay/pdb
PDB entry 9qay coloured by chain, front view.
PDB entry 9qay coloured by chain, side view.
PDB entry 9qay coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Balch S, Sekne Z, Franco-Echevarría E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD
Science 389 eadr5817 (2025)
PMID: 40638752
Related structures: EMD-52979

Function and Biology Details

Reaction catalysed: 
[DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) +diphosphate.]
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-308421 (preferred)
Entry contents:
4 distinct polypeptide molecules
1 distinct DNA molecule
1 distinct RNA molecule
Macromolecules (6 distinct):
Telomerase reverse transcriptase Chain: A
Molecule details ›
Chain: A
Length: 1132 amino acids
Theoretical weight: 127.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14746 (Residues: 1-1132; Coverage: 100%)
Gene names: EST2, TCS1, TERT, TRT
Sequence domains:
Histone H2A Chain: L
Molecule details ›
Chain: L
Length: 130 amino acids
Theoretical weight: 14.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: B2R5B3 (Residues: 1-130; Coverage: 100%)
Sequence domains:
Histone H2B Chain: M
Molecule details ›
Chain: M
Length: 166 amino acids
Theoretical weight: 18.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: B4DR52 (Residues: 1-166; Coverage: 100%)
Sequence domains: Core histone H2A/H2B/H3/H4
Adrenocortical dysplasia protein homolog Chain: O
Molecule details ›
Chain: O
Length: 458 amino acids
Theoretical weight: 49.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q96AP0 (Residues: 1-458; Coverage: 100%)
Gene names: ACD, PIP1, PTOP, TINT1, TPP1
Sequence domains: Shelterin complex subunit, TPP1/ACD
DNA (5'-D(P*GP*TP*TP*AP*GP*GP*G)-3') Chain: N
Molecule details ›
Chain: N
Length: 7 nucleotides
Theoretical weight: 2.19 KDa
hTR, human telomerase RNA (253-mer) Chain: B
Molecule details ›
Chain: B
Length: 451 nucleotides
Theoretical weight: 145.48 KDa
Sequence domains: Vertebrate telomerase RNA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-52979
Expression systems:
  • Homo sapiens
  • Spodoptera

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