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author:"Ghanim GE"

Filter By

Current Database

  • EMDB [27]
  • EMPIAR [2]

Current status

  • REL [29]

Sample type

  • Complex [27]
  • Protein [25]
  • DNA [20]
  • RNA [20]
  • Ligand [8]

Organism

  • Homo sapiens [25]
  • Drosophila melanogaster [2]
  • Synthetic construct [1]

EM Method

  • Single-particle [27]

Resolution

  • ≥ 2Å and < 3Å [6]
  • ≥ 3Å and < 4Å [15]
  • ≥ 4Å and < 5Å [3]
  • ≥ 6Å and < 8Å [3]

Model molecular weight

  • 100-250 kDa [3]
  • 250-500 kDa [14]
  • 500-1000 kDa [2]

Release Date

  • 2025 [13]
  • 2024 [2]
  • 2023 [3]
  • 2022 [4]
  • 2021 [5]
  • 2019 [2]

Author by name

  • Ghanim GE [28]
  • Nguyen THD [26]
  • Sekne Z [14]
  • Van Roon Am [14]
  • Das R [13]
  • Balch S [10]
  • Van Roon Amm [9]
  • Ding Y [8]
  • Franco-echevarria E [8]
  • Kretsch RC [8]
  • Ludzia P [8]
  • Sun W [8]
  • Thorkelsson S [8]
  • Yu H [8]
  • Hu H [7]
  • Sigurdur TR [6]
  • Collins K [5]
  • Fountain AJ [5]
  • Rangan R [5]
  • Boulanger J [4]
  • Ahsan B [3]
  • Oluwole A [3]
  • Oluwole AO [3]
  • Peak-chew S [3]
  • Peak-chew SY [3]
  • Robinson CV [3]
  • Kellogg EH [2]
  • Nogales E [2]
  • Rio DC [2]
  • Thorkelsson SR [2]
  • Ghanim GEG [1]

Author by ORCID

  • Ghanim GE [27]
  • Nguyen THD [25]
  • Das R [12]
  • Sekne Z [12]
  • Franco-echevarria E [8]
  • Ludzia P [8]
  • Yu H [8]
  • Kretsch RC [8]
  • Thorkelsson S [8]
  • Ding Y [8]
  • Sun W [8]
  • Balch S [8]
  • Hu H [7]
  • Van Roon Am [7]
  • Rangan R [4]
  • Boulanger J [4]
  • Robinson CV [3]
  • Oluwole AO [3]
  • Ahsan B [3]
  • Nogales E [2]
  • Rio DC [2]

Journal

  • SCIENCE [17]
  • NATURE [5]
  • SCI ADV [3]
  • NAT COMMUN [2]
  • NAT STRUCT MOL BIOL [2]

Software

  • RELION [26]
  • CTFFIND [14]
  • UCSF CHIMERAX [2]
  • CRYOSPARC [1]

Microscope

  • FEI TITAN KRIOS [20]
  • TFS KRIOS [5]
  • FEI TECNAI ARCTICA [2]

Electron Source

  • FIELD EMISSION GUN [27]

Film or detector model

  • GATAN K3 6K X 4K [21]
  • TFS FALCON 4I 4K X 4K [4]
  • GATAN K2 SUMMIT 4K X 4K [2]

EMPIAR Experiment type

  • EMDB [2]

EMPIAR Image category

  • MICROGRAPHS - MULTIFRAME [2]
  • PICKED PARTICLES - SINGLE FRAME - PROCESSED [1]

External links

  • AlphaFold DB [25]
  • PDBe-Kb [25]
  • UniProt [25]
  • PDB [19]
  • Pfam [19]
  • InterPro [14]
  • Complex Portal [12]
  • Gene Ontology [12]
  • ChEBI [8]
  • ChEMBL [8]
  • DrugBank [8]
  • EMPIAR [8]
  • EMDB [2]
  • SCOP2 [2]
Sort by: Download
Showing 1 - 10 of 29. Page 1 of 3
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EMD-52976
Download Map
3D View
Consensus dimer structure of human telomerase
Release date: July 16, 2025
Resolution: 6.2 Å
EM Method: Single-particle

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52978
Download Map
3D View
The catalytic core with C2 symmetry of human telomerase dimer
Release date: July 16, 2025
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9qax
Q-score: 0.259

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52979
Download Map
3D View
Catalytic core 1 of dimeric human telomerase
Release date: July 16, 2025
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9qay
Q-score: 0.226

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52980
Download Map
3D View
Catalytic core 2 of dimeric human telomerase
Release date: July 16, 2025
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9qaz
Q-score: 0.233

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52981
Download Map
3D View
Catalytic core 1 of human telomerase dimer from particles common to both catalytic cores of the dimer
Release date: July 16, 2025
Resolution: 4.1 Å
EM Method: Single-particle

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52982
Download Map
3D View
Catalytic core 2 of the telomerase dimer with common particles to both catalytic cores of the dimer
Release date: July 16, 2025
Resolution: 3.9 Å
EM Method: Single-particle

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52983
Download Map
3D View
H/ACA RNP protomer of human telomerase dimer
Release date: July 16, 2025
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9qb2
Q-score: 0.448

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMD-52984
Download Map
3D View
Dimer structure of H/ACA RNP lobe of human telomerase
Release date: July 16, 2025
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9qb3
Q-score: 0.261

Balch S, Sekne Z, Franco-Echevarria E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD

Science (2025) 389 pp. eadr5817-eadr5817 [ Pubmed: 40638752 DOI: doi:10.1126/science.adr5817 ]

EMPIAR-12450
Related EMDB
EMD-52070 EMD-52073 EMD-52072 EMD-52071
Cryo-EM Structures of human LINE-1 ORF2p target-primed reverse transcription complex
Release date: April 7, 2025
Dataset size: 5.1 TB
Experiment type: EMDB

Ghanim GE, Hu H, Boulanger J, Nguyen THD

Science (2025) [ Pubmed: 40048554 DOI: 10.1126/science.ads8412 ]

Image sets:
  • Polished particle stack of the ORF2p TPRT complex with the fingers domain in a closed conformation (EMD-52071)
  • Unaligned multi-frame micrographs of the human LINE-1 ORF2p TPRT complex
  • Polished particle stack of the ORF2p TPRT complex consensus reconstruction (EMD-52070)
  • Polished particle stack of the ORF2p TPRT complex with the EN domain resolved (EMD-52073)
  • Polished particle stack of the ORF2p TPRT complex with the fingers domain in an open conformation (EMD-52072)
[Show more]
EMD-52070
Download Map
3D View
Raw data
EMPIAR-12450
The Human LINE-1 ORF2p target-primed reverse transcription complex
Release date: March 12, 2025
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 9hdo
Q-score: 0.591

Ghanim GE, Hu H, Boulanger J, Nguyen THD

Science (2025) 388 pp. eads8412-eads8412 [ DOI: doi:10.1126/science.ads8412 Pubmed: 40048554 ]

Sort by: Download
Showing 1 - 10 of 29. Page 1 of 3
Display:
Statistics
×

Download












































Preview first 10
Download

Filter By

Current Database

  • EMDB [27]
  • EMPIAR [2]

Current status

  • REL [29]

Sample type

  • Complex [27]
  • Protein [25]
  • DNA [20]
  • RNA [20]
  • Ligand [8]

Organism

  • Homo sapiens [25]
  • Drosophila melanogaster [2]
  • Synthetic construct [1]

EM Method

  • Single-particle [27]

Resolution

  • ≥ 2Å and < 3Å [6]
  • ≥ 3Å and < 4Å [15]
  • ≥ 4Å and < 5Å [3]
  • ≥ 6Å and < 8Å [3]

Model molecular weight

  • 100-250 kDa [3]
  • 250-500 kDa [14]
  • 500-1000 kDa [2]

Release Date

  • 2025 [13]
  • 2024 [2]
  • 2023 [3]
  • 2022 [4]
  • 2021 [5]
  • 2019 [2]

Author by name

  • Ghanim GE [28]
  • Nguyen THD [26]
  • Sekne Z [14]
  • Van Roon Am [14]
  • Das R [13]
  • Balch S [10]
  • Van Roon Amm [9]
  • Ding Y [8]
  • Franco-echevarria E [8]
  • Kretsch RC [8]
  • Ludzia P [8]
  • Sun W [8]
  • Thorkelsson S [8]
  • Yu H [8]
  • Hu H [7]
  • Sigurdur TR [6]
  • Collins K [5]
  • Fountain AJ [5]
  • Rangan R [5]
  • Boulanger J [4]
  • Ahsan B [3]
  • Oluwole A [3]
  • Oluwole AO [3]
  • Peak-chew S [3]
  • Peak-chew SY [3]
  • Robinson CV [3]
  • Kellogg EH [2]
  • Nogales E [2]
  • Rio DC [2]
  • Thorkelsson SR [2]
  • Ghanim GEG [1]

Author by ORCID

  • Ghanim GE [27]
  • Nguyen THD [25]
  • Das R [12]
  • Sekne Z [12]
  • Franco-echevarria E [8]
  • Ludzia P [8]
  • Yu H [8]
  • Kretsch RC [8]
  • Thorkelsson S [8]
  • Ding Y [8]
  • Sun W [8]
  • Balch S [8]
  • Hu H [7]
  • Van Roon Am [7]
  • Rangan R [4]
  • Boulanger J [4]
  • Robinson CV [3]
  • Oluwole AO [3]
  • Ahsan B [3]
  • Nogales E [2]
  • Rio DC [2]

Journal

  • SCIENCE [17]
  • NATURE [5]
  • SCI ADV [3]
  • NAT COMMUN [2]
  • NAT STRUCT MOL BIOL [2]

Software

  • RELION [26]
  • CTFFIND [14]
  • UCSF CHIMERAX [2]
  • CRYOSPARC [1]

Microscope

  • FEI TITAN KRIOS [20]
  • TFS KRIOS [5]
  • FEI TECNAI ARCTICA [2]

Electron Source

  • FIELD EMISSION GUN [27]

Film or detector model

  • GATAN K3 6K X 4K [21]
  • TFS FALCON 4I 4K X 4K [4]
  • GATAN K2 SUMMIT 4K X 4K [2]

EMPIAR Experiment type

  • EMDB [2]

EMPIAR Image category

  • MICROGRAPHS - MULTIFRAME [2]
  • PICKED PARTICLES - SINGLE FRAME - PROCESSED [1]

External links

  • AlphaFold DB [25]
  • PDBe-Kb [25]
  • UniProt [25]
  • PDB [19]
  • Pfam [19]
  • InterPro [14]
  • Complex Portal [12]
  • Gene Ontology [12]
  • ChEBI [8]
  • ChEMBL [8]
  • DrugBank [8]
  • EMPIAR [8]
  • EMDB [2]
  • SCOP2 [2]