We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 8yez

Electron Microscopy
3.3Å resolution

Human PIEZO1

Released:
DOI: 10.2210/pdb8yez/pdb
PDB entry 8yez coloured by chain, front view.
PDB entry 8yez coloured by chain, side view.
PDB entry 8yez coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human PIEZO1 and its slow inactivating channelopathy mutants.
Shan Y, Guo X, Zhang M, Chen M, Li Y, Zhang MF, Pei D
Elife (2024)
Related structures: EMD-39205

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-284383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Piezo-type mechanosensitive ion channel component 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 2521 amino acids
Theoretical weight: 287.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92508 (Residues: 1-2521; Coverage: 100%)
Gene names: FAM38A, KIAA0233, PIEZO1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand L9Q 6 x L9Q
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-39205
Expression system: Homo sapiens

Quick links