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EMD-0527
Chronic traumatic encephalopathy Type I Tau filament
EMD-0527
Helical reconstruction2.3 Å
Deposition: 07/02/2019Map released: 27/03/2019
Last modified: 10/07/2024
Sample Organism:
Homo sapiens
Sample: Tau filaments extracted from the temporal cortex of a patient with chronic traumatic encephalopathy
Fitted models: 6nwp
Deposition Authors: Falcon B
,
Zivanov J
Sample: Tau filaments extracted from the temporal cortex of a patient with chronic traumatic encephalopathy
Fitted models: 6nwp
Deposition Authors: Falcon B
,
Zivanov J
Grant Support:
- Medical Research Council (United Kingdom): MC_UP_A025_1013 (United Kingdom)
- Medical Research Council (United Kingdom): MC_U105184291 (United Kingdom)
- European Union: Joint Programme- Neurodegeneration Research REfrAME (United Kingdom)
- Innovative Medicines Initiative: 116060 (United Kingdom)
- National Institutes of Health/National Institute on Aging (NIH/NIA): P30AG010133 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): U01NS110437 (United States)
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Falcon B ,
Zivanov J,
Zhang W ,
Murzin AG,
Garringer HJ ,
Vidal R ,
Crowther RA,
Newell KL,
Ghetti B,
Goedert M,
Scheres SHW
(2019) Nature , 568 , 420 - 423
,
Zivanov J,
Zhang W ,
Murzin AG,
Garringer HJ ,
Vidal R ,
Crowther RA,
Newell KL,
Ghetti B,
Goedert M,
Scheres SHW
(2019) Nature , 568 , 420 - 423