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EMD-23838
Signal subtracted reconstruction of AAA2, AAA3, and AAA4 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Map 4
EMD-23838
Single-particle3.5 Å

Map released: 26/05/2021
Last modified: 29/05/2024
Sample Organism:
Saccharomyces cerevisiae
Sample: Dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound
Fitted models: 7mi3
Deposition Authors: Santarossa CC, Coudray N, Urnavicius L, Ekiert DC
,
Bhabha G
,
Kapoor TM
Sample: Dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound
Fitted models: 7mi3
Deposition Authors: Santarossa CC, Coudray N, Urnavicius L, Ekiert DC



Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM98579 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35 GM130234-01 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R00GM112982 (United States)
- Damon Runyon Cancer Research Foundation: DFS-20-16 (United States)
Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Santarossa CC,
Mickolajczyk KJ,
Steinman JB,
Urnavicius L,
Chen N,
Hirata Y,
Fukase Y
,
Coudray N,
Ekiert DC
,
Bhabha G
,
Kapoor TM
(2021) Cell Chem Biol , 28 , 1460 - 1473.e15




(2021) Cell Chem Biol , 28 , 1460 - 1473.e15